Acalculous Cholecystitis | Causes, Risk Factors and Diagnosis

Learn about acalculous cholecystitis, its causes, risk factors, and diagnostic methods.

  Tue , June 09 2026 / 07:55 PM Updated At: 2026-06-09 19:55:15


By: Dr. Ahmed Abdel Salam Abdel Kader Ibrahim

🟢 Acalculous Cholecystitis

Acalculous cholecystitis is an inflammation of the gallbladder without gallstones ⚠️
It usually occurs as a complication of a severe medical or surgical condition.


🧪 Causes

1. Increased bile viscosity

Bile stasis and thickened bile may occur in:

🏥 Critically ill patients

🦠 Sepsis patients

💉 Long-term TPN patients

❤️ Cardiac patients

🩸 Diabetic patients

❗ Lack of oral feeding reduces cholecystokinin, leading to poor gallbladder contraction.


2. Gallbladder ischemia

Caused by:

🌡️ Fever

💧 Dehydration

❤️ Heart failure

➡️ This leads to reduced blood flow and gallbladder wall damage.


⚠️ Risk Factors

🩸 Diabetes mellitus

🦠 HIV infection

🧬 Vascular diseases

🧫 Hepatitis A

🏥 Sepsis

❤️ Cardiac or aortic surgery

⛔ Prolonged fasting & malnutrition

🏥 ICU patients

🔥 Burns & trauma

💊 Opioid use

⚠️ Multi-organ failure


🔬 Diagnosis

Diagnosis is based on:

🩸 CBC test

🧪 Liver function tests

🩻 Ultrasound imaging

🖥️ CT scan

📌 Imaging findings:

Gallbladder wall thickening > 3 mm

Gallbladder distension

Abscess or perforation in severe cases

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